Mitochondrial network of cancer cells



We study the molecular mechanisms by which mitochondria regulate cell death in models of mitochondrial DNA diseases, muscular dystrophies and tumors. We are characterizing the composition and regulation of the permeability transition pore, a mitochondrial channel whose opening induces cell death, and we are investigating how mitochondrial metabolism contributes to tumorigenesis.


5 recent publications

  • Carrer, A., Tommasin, L., Šileikytė, J., Ciscato, F., Filadi, R., Urbani, A., Forte, M., Rasola, A., Szabò, I., Carraro, M. and Bernardi, P. (2021) Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase. Nat. Commun. 12, 4835
  • Masgras I, Laquatra C, Cannino G, Serapian SA, Colombo G, Rasola A. The molecular chaperone TRAP1 in cancer: from the basics of biology to pharmacological targeting. Semin Cancer Biol. 2021 Jul 6:S1044-579X(21)00196-6
  • Laquatra, C., Sanchez-Martin, C., Dinarello, A., Cannino, G., Minervini, G., Moroni, E., Schiavone, M., Tosatto, S., Argenton, F., Colombo. G., Bernardi, P., Masgras, I. and Rasola, A. (2021) HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia. Cell Death Dis. 12, 434
  • Carraro, M., Jones, K., Sartori, G., Schiavone, M., Antonucci, S., Kucharczyk, R., di Rago, J.-P., Franchin, C., Arrigoni, G., Forte, M. and Bernardi, P. (2020) The Unique Cysteine of F-ATP Synthase OSCP Subunit Participates in Modulation of the Permeability Transition Pore. Cell Rep. 32, 108095
  • Sanchez-Martin C, Moroni E, Ferraro M, Laquatra C, Cannino G, Masgras I, Negro A, Quadrelli P, Rasola A, Colombo G (2020) Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1. Cell Rep 31:107531

More publications



  • AIRC (Italian Association for Cancer Research)
  • Telethon, Italy
  • Università di Padova
  • Fondation Leducq, France
  • Children's Tumor Foundation, USA
  • Neurofibromatosis Therapeutic Acceleration Program, USA