Marco Giorgio received the B.Sc. degree in Biology upon working on transgenic model of HBV at the University of Rome. He did the post-graduate training at the IRBM in Pomezia, studying the biochemistry of IL-6. Awarded by a fellowship from AIRC, he investigated gene function in transgenic mice and generated cancer models at the Regina Elena cancer institute in Rome. Then, for two years at the MSKCC in New York, he started working on the genetic link between cancer and aging. He received the PhD degree in Biotechnology discussing a thesis on the p66Shc aging gene and in 1998 joined the Department of Experimental Oncology at IEO-Milan as staff scientist where, he continued investigating the mechanisms of aging involved in tumorigenesis and currently collaborates to detail the metabolic adaptation of metastasis. Since 2018 he is associated professor of Biochemistry at the Department of Biomedical Science of the University of Padova where he carries on investigating the molecular mechanisms of aging.

What happen, at molecular level, within the mammalian cell, during aging?

Our working hypothesis is that biochemical "errors" that occur over time, at first remodel cellular phenotype trough processes of plasticity and selective adaptation, then accumulate and determine typical aging dysfunctions.

At the experimental level, Giorgio’s lab focuses on the interactions between bioenergetics, redox balance and DNA metabolism by testing the long-term consequences of the adaptive circuits that are established between these processes in different experimental systems, including human samples, by omics approaches.

Major contribution given in this field is characterization of the p66Shc "aging gene" and the role of mitochondrial redox signaling in the onset of aging associated diseases.

Giorgio’s studies are reported in more than a hundred publications in international peer reviewed journals in the fields of biochemistry, molecular biology, genetics and medicine for an H index of 40 according to "Scopus - Orcid - Web of Science".

Full lists of these publications are available at:

https://www.researchgate.net/profile/Marco-Giorgio

or

https://scholar.google.com/citations?hl=it&user=qDBFcb0AAAAJ

  • University of Padova
  • Ministry of Health  -  Grant RF
  • European Institute of Oncology, Milan

Teaching activities