Lorenzo PINNA
Title: Professor Emeritus
Telephone: 049 827-6108
E-mail: lorenzo.pinna@unipd.it
Group Website: [link]
1962. University of Padova, graduated with laude in Biological Sciences.
1965-1966 Postdoctoral fellow at Johns Hopkins University Medical School, Baltimore, USA.
1968-1975 Assistant professor at the University of Padova, with tenures of Biochemistry and Medical Chemistry.
1975-2012 Full Professor of Medical Chemistry and Biochemistry at the University of Padova.
1990 Visiting Professor, the University of Melbourne, Australia.
2013 Visiting Professor, the University of Ulm, Germany
2013-present Emeritus Professor, the University of Padova.
Institutional Commitments at the University of Padova
1984-1993 Director of the Department of Biological Chemistry.
1987-1996 Coordinator of the “commissione Scientifica delì’Area Biologica”.
1990-2003 Coordinator of the PhD course in Biochemistry and Biophysics.
1996-2001 President of the “Commissione Scientifica” of the Medical Faculty.
2002-2005 Director of the Department of Biological Chemistry.
2004-2007 Director of the PhD School in Biochemistry and Biotechnologies.
2010-2012 Director of the interdipartimental Centre for the Study of Cellular Signalling.
Lorenzo A. Pinna (orcid ID 0000-0002-8856-4956) was a pioneer in the field of protein phosphorylation (first paper published in 1963) becoming later an expert of signal transduction mediated by phosphorylation, with special reference to the molecular enzymology of oncogenic protein kinases and the development of kinase inhibitors with anti-cancer potential. He provided critical contributions to the definition of the consensus sequences that are recognized by individual protein kinases, to the understanding of the biological functions of acidophilic protein kinases and to the identification of the atypical kinase that is responsible for the generation of the phospho-secretome. Presently he is an associated member of the CNR Institute of Neurochemistry, being responsible for a research project funded by AIRC He has published 400 papers which received 25912 citations , with a H-index 84 (Google scholar November 2020). His latest 5 years (2015-2020) H-index is 41. For his scientific achievements he was awarded the “Award Biotech ‘98” prize and was nominated honorary member of the Italian Biochemical Society.
A full list of his papersis available at https://scholar.google.it/citations?user=VUwFX84AAAAJ&hl=it
1. Cesaro, L., and Pinna, L. A. (2020) Prevalence and significance of the commonest phosphorylated motifs in the human proteome: a global analysis. Cell Mol Life Sci 77, 5281-5298
2. Borgo, C., Franchin, C., Cesaro, L., Zaramella, S., Arrigoni, G., Salvi, M., and Pinna, L. A. (2019) A proteomics analysis of CK2β(-/-) C2C12 cells provides novel insights into the biological functions of the non-catalytic β subunit. FEBS J. 286, 1561-1575.
3. Cozza, G., Moro, E., Black, M., Marin, O., Salvi, M., Venerando, A., Tagliabracci, V. S., and Pinna, L. A. (2018) The Golgi "casein kinase" Fam20C is a genuine "phosvitin kinase" and phosphorylates polyserine stretches devoid of the canonical consensus. FEBS J. 285, 4674-4683.
4. Borgo, C., Franchin, C., Scalco, S., Bosello-Travain, V., Donella-Deana, A., Arrigoni, G., Salvi, M., and Pinna, L. A. (2017) Generation and quantitative proteomics analysis of CK2α/α'((-/-)) cells. Sci Rep 7, 42409.
5. Venerando, A., Cesaro, L., and Pinna, L. A. (2017) From phosphoproteins to phosphoproteomes: a historical account. FEBS J.
6. Cozza, G., and Pinna, L. A. (2016) Casein kinases as potential therapeutic targets. Expert Opin. Ther. Targets 20, 319-340.
7. Tagliabracci, V. S., Wiley, S. E., Guo, X., Kinch, L. N., Durrant, E., Wen, J., Xiao, J., Cui, J., Nguyen, K. B., Engel, J. L., Coon, J. J., Grishin, N., Pinna, L. A., Pagliarini, D. J., and Dixon, J. E. (2015) A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell 161, 1619-1632.
8. Cozza, G., Girardi, C., Ranchio, A., Lolli, G., Sarno, S., Orzeszko, A., Kazimierczuk, Z., Battistutta, R., Ruzzene, M., and Pinna, L. A. (2014) Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential. Cell. Mol. Life Sci. 71, 3173-3185
9. Venerando, A., Ruzzene, M., and Pinna, L. A. (2014) Casein kinase: the triple meaning of a misnomer. Biochem. J. 460, 141-156.
10. Tagliabracci, V. S., Pinna, L. A., and Dixon, J. E. (2013) Secreted protein kinases. Trends Biochem. Sci. 38, 121-130.