ROSARIO RIZZUTO
Title: Professor
Telephone: 049 827-6061
E-mail: rosario.rizzuto@unipd.it
Group Website: [link]
2019-date: Coimbra Group Universities - Member of the Rectors’ Advisory Group
2019-date: European University Association (EUA) - Member of the Research Policy Working Group
2019-date: Conference of the Rectors of Italian Universities (CRUI), Rome, Italy - Member of the steering committee (“Giunta”) and delegate for Research and Innovation, Coordinator of the Research Committee
2015-date: University of Padua, Padua, Italy - Rector
2009-2015: Department of Biomedical Sciences, University of Padua, Padua, Italy - Head of the Department
2008-date: Department of Biomedical Sciences, University of Padua, Padua, Italy, Full Professor of General Pathology
2007-2008: School of Pharmacy, University of Ferrara, Ferrara, Italy - Dean of the School
2002-2008: School of Pharmacy, University of Ferrara, Ferrara, Italy - Full Professor of General Pathology
1998-2002: School of Pharmacy, University of Ferrara, Ferrara, Italy - Associate Professor of General Pathology
1992-1998: School of Medicine, University of Padua, Padua, Italy - Assistant Professor of General Pathology
1991-1992: Department of Experimental Biomedical Sciences, University of Padua, Padua, Italy - Research Associate
My research interests have been centered on the study of cellular signalling, with special focus on intracellular calcium homeostasis. I developed an innovative methodology, organelle targeting of recombinant luminescent (aequorin, luciferase) and fluorescent (GFP) proteins, that allowed novel insight in the fields of calcium signalling, cellular metabolism and organelle morphology. New concepts have been acquired, which include the participation of mitochondria in cellular Ca2+ homeostasis and their role in translating calcium signals in effects as diverse as stimulation of metabolism and induction of cell death, the occurrence of tight signalling interactions between the endoplasmic reticulum and mitochondria, the identification of the Golgi apparatus as an agonist-sensitive Ca2+ store, and the major Ca2+ rises occurring under the plasma membrane upon cell stimulation, to cite a few. In 2011, I identified the mitochondrial calcium uniporter (MCU), the only fundamental component of the cellular calcium signalling machinery yet to be discovered. This result has opened the molecular era of mitochondrial Ca2+ homeostasis, that combines molecular insight into the structure/function relationship of MCU and its regulators and the possibility of manipulating mitochondrial Ca2+ handling in cultured cells and animal models, with the goal of clarifying its role in the physiological regulation of tissues and in the pathogenesis of the most prevalent human diseases (neurodegenerative disorders, ischemic heart disease, cancer).
286. The Mitochondrial Ca2+ Uptake and the Fine-Tuning of Aerobic Metabolism.
Gherardi G, Monticelli H, Rizzuto R, Mammucari C. Front Physiol. 2020 Oct 7;11:554904. doi:10.3389/fphys.2020.554904. eCollection 2020.
285. Mitochondrial ion channels as targets for cardioprotection.
Hausenloy DJ, Schulz R, Girao H, Kwak BR, De Stefani D, Rizzuto R, Bernardi P, Di Lisa F. J Cell Mol Med. 2020 Jul;24(13):7102-7114. doi: 10.1111/jcmm.15341. Epub 2020 Jun 3.
284. The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.
Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA. Diabetologia. 2020 Jul;63(7):1368-1381. doi: 10.1007/s00125-020-05148-x. Epub 2020 Apr 29.
283. A High-Throughput Screening Identifies MICU1 Targeting Compounds.
Di Marco G, Vallese F, Jourde B, Bergsdorf C, Sturlese M, De Mario A, Techer-Etienne V, Haasen D, Oberhauser B, Schleeger S, Minetti G, Moro S, Rizzuto R, De Stefani D, Fornaro M, Mammucari C. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. doi: 10.1016/j.celrep.2020.01.081.
282. Aldosterone Stimulates Its Biosynthesis Via a Novel GPER-Mediated Mechanism.
Caroccia B, Seccia TM, Piazza M, Prisco S, Zanin S, Iacobone M, Lenzini L, Pallafacchina G, Domening O, Poglitsch M, Rizzuto R, Rossi GP. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6316-6324. doi: 10.1210/jc.2019-00043.
281. Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death.
Granatiero V, Pacifici M, Raffaello A, De Stefani D, Rizzuto R. Oxid Med Cell Longev. 2019 Oct 16;2019:1681254. doi: 10.1155/2019/1681254. eCollection 2019.
280. Crosstalk between Mitochondrial Ca2+ Uptake and Autophagy in Skeletal Muscle.
Gherardi G, Di Marco G, Rizzuto R, Mammucari C. Oxid Med Cell Longev. 2019 Sep 8;2019:1845321. doi: 10.1155/2019/1845321. eCollection 2019.
279. Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, Checchetto V, Campo A, Menabò R, Di Marco G, Di Lisa F, Szabo I, Rizzuto R, De Stefani D. Nature. 2019 Aug;572(7771):609-613. doi: 10.1038/s41586-019-1498-3. Epub 2019 Aug 21.
278. Protein kinase CK2 subunits exert specific and coordinated functions in skeletal muscle differentiation and fusogenic activity.
Salizzato V, Zanin S, Borgo C, Lidron E, Salvi M, Rizzuto R, Pallafacchina G, Donella-Deana A. FASEB J. 2019 Oct;33(10):10648-10667. doi: 10.1096/fj.201801833RR. Epub 2019 Jul 3.
277. Crosstalk between Calcium and ROS in Pathophysiological Conditions.
Feno S, Butera G, Vecellio Reane D, Rizzuto R, Raffaello A. Oxid Med Cell Longev. 2019 Apr 24;2019:9324018. doi: 10.1155/2019/9324018. eCollection 2019.
276. Coming together to define membrane contact sites.
Scorrano L, De Matteis MA, Emr S, Giordano F, Hajnóczky G, Kornmann B, Lackner LL, Levine TP, Pellegrini L, Reinisch K, Rizzuto R, Simmen T, Stenmark H, Ungermann C, Schuldiner M. Nat Commun. 2019 Mar 20;10(1):1287. doi: 10.1038/s41467-019-09253-3.
275. Publisher Correction: Parkin-dependent regulation of the MCU complex component MICU1.
Matteucci A, Patron M, Vecellio Reane D, Gastaldello S, Amoroso S, Rizzuto R, Brini M, Raffaello A, Calì T. Sci Rep. 2019 Mar 12;9(1):4665. doi: 10.1038/s41598-018-37929-1.
274. Methods to Measure Intracellular Ca2+ Concentration Using Ca2+-Sensitive Dyes.
Zanin S, Lidron E, Rizzuto R, Pallafacchina G. Methods Mol Biol. 2019;1925:43-58. doi: 10.1007/978-1-4939-9018-4_4.
273. Recent advances in the molecular mechanism of mitochondrial calcium uptake.
Pallafacchina G, Zanin S, Rizzuto R. F1000Res. 2018 Nov 28;7:F1000 Faculty Rev-1858. doi: 10.12688/f1000research.15723.1. eCollection 2018.
272. Melatonin activates FIS1, DYN1, and DYN2 Plasmodium falciparum related-genes for mitochondria fission: Mitoemerald-GFP as a tool to visualize mitochondria structure.
Scarpelli PH, Tessarin-Almeida G, Viçoso KL, Lima WR, Borges-Pereira L, Meissner KA, Wrenger C, Raffaello A, Rizzuto R, Pozzan T, Garcia CRS. J Pineal Res. 2019 Mar;66(2):e12484. doi: 10.1111/jpi.12484. Epub 2018 Oct 5.
271. Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF-β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans.
Carnevale D, Facchinello N, Iodice D, Bizzotto D, Perrotta M, De Stefani D, Pallante F, Carnevale L, Ricciardi F, Cifelli G, Da Ros F, Casaburo M, Fardella S, Bonaldo P, Innocenzi G, Rizzuto R, Braghetta P, Lembo G, Bressan GM. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2484-2497. doi: 10.1161/ATVBAHA.118.311115.
270. Parkin-dependent regulation of the MCU complex component MICU1.
Matteucci A, Patron M, Vecellio Reane D, Gastaldello S, Amoroso S, Rizzuto R, Brini M, Raffaello A, Calì T. Sci Rep. 2018 Sep 21;8(1):14199. doi: 10.1038/s41598-018-32551-7.
269. Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference.
Gherardi G, Nogara L, Ciciliot S, Fadini GP, Blaauw B, Braghetta P, Bonaldo P, De Stefani D, Rizzuto R, Mammucari C. Cell Death Differ. 2019 Jan;26(2):362-381. doi: 10.1038/s41418-018-0191-7. Epub 2018 Sep 19.
268. Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock.
Dyar KA, Hubert MJ, Mir AA, Ciciliot S, Lutter D, Greulich F, Quagliarini F, Kleinert M, Fischer K, Eichmann TO, Wright LE, Peña Paz MI, Casarin A, Pertegato V, Romanello V, Albiero M, Mazzucco S, Rizzuto R, Salviati L, Biolo G, Blaauw B, Schiaffino S, Uhlenhaut NH. PLoS Biol. 2018 Aug 10;16(8):e2005886. doi: 10.1371/journal.pbio.2005886. eCollection 2018 Aug.
267. Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling.
Cieri D, Vicario M, Vallese F, D'Orsi B, Berto P, Grinzato A, Catoni C, De Stefani D, Rizzuto R, Brini M, Calì T. Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3247-3256. doi: 10.1016/j.bbadis.2018.07.011. Epub 2018 Jul 11.
266. Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism.
Díaz-Vegas AR, Cordova A, Valladares D, Llanos P, Hidalgo C, Gherardi G, De Stefani D, Mammucari C, Rizzuto R, Contreras-Ferrat A, Jaimovich E. Front Physiol. 2018 Jun 25;9:791. doi: 10.3389/fphys.2018.00791. eCollection 2018.
265. MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.
Patron M, Granatiero V, Espino J, Rizzuto R, De Stefani D. Cell Death Differ. 2019 Jan;26(1):179-195. doi: 10.1038/s41418-018-0113-8. Epub 2018 May 3.
264. MCU-knockdown attenuates high glucose-induced inflammation through regulating MAPKs/NF-κB pathways and ROS production in HepG2 cells.
Panahi G, Pasalar P, Zare M, Rizzuto R, Meshkani R. PLoS One. 2018 Apr 30;13(4):e0196580. doi: 10.1371/journal.pone.0196580. eCollection 2018.
263. Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models.
Mammucari C, Raffaello A, Vecellio Reane D, Gherardi G, De Mario A, Rizzuto R. Pflugers Arch. 2018 Aug;470(8):1165-1179. doi: 10.1007/s00424-018-2123-2. Epub 2018 Mar 15.
262. High glucose induces inflammatory responses in HepG2 cells via the oxidative stress-mediated activation of NF-κB, and MAPK pathways in HepG2 cells.
Panahi G, Pasalar P, Zare M, Rizzuto R, Meshkani R. Arch Physiol Biochem. 2018 Dec;124(5):468-474. doi: 10.1080/13813455.2018.1427764. Epub 2018 Jan 24.
261. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23.
260. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.
Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11.
259. Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.
Zaglia T, Ceriotti P, Campo A, Borile G, Armani A, Carullo P, Prando V, Coppini R, Vida V, Stølen TO, Ulrik W, Cerbai E, Stellin G, Faggian G, De Stefani D, Sandri M, Rizzuto R, Di Lisa F, Pozzan T, Catalucci D, Mongillo M. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9006-E9015. doi: 10.1073/pnas.1708772114. Epub 2017 Oct 9.
258. The MCU complex in cell death.
Penna E, Espino J, De Stefani D, Rizzuto R. Cell Calcium. 2018 Jan;69:73-80. doi: 10.1016/j.ceca.2017.08.008. Epub 2017 Aug 25.
257. Increased mitochondrial calcium uniporter in adipocytes underlies mitochondrial alterations associated with insulin resistance.
Wright LE, Vecellio Reane D, Milan G, Terrin A, Di Bello G, Belligoli A, Sanna M, Foletto M, Favaretto F, Raffaello A, Mammucari C, Nitti D, Vettor R, Rizzuto R. Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E641-E650. doi: 10.1152/ajpendo.00143.2016. Epub 2017 Aug 8.
256. Role of p66shc in skeletal muscle function.
Granatiero V, Gherardi G, Vianello M, Salerno E, Zecchini E, Toniolo L, Pallafacchina G, Murgia M, Blaauw B, Rizzuto R, Mammucari C. Sci Rep. 2017 Jul 24;7(1):6283. doi: 10.1038/s41598-017-06363-0.
255. Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease.
Mammucari C, Gherardi G, Rizzuto R. Front Oncol. 2017 Jul 10;7:139. doi: 10.3389/fonc.2017.00139. eCollection 2017.
254. Ca2+ Measurements in Mammalian Cells with Aequorin-based Probes.
Tosatto A, Rizzuto R, Mammucari C. Bio Protoc. 2017 Mar 5;7(5):e2155. doi: 10.21769/BioProtoc.2155.
253. Mitochondrial Calcium Handling in Physiology and Disease.
Granatiero V, De Stefani D, Rizzuto R. Adv Exp Med Biol. 2017;982:25-47. doi: 10.1007/978-3-319-55330-6_2.
252. Physiological Characterization of a Plant Mitochondrial Calcium Uniporter in Vitro and in Vivo.
Teardo E, Carraretto L, Wagner S, Formentin E, Behera S, De Bortoli S, Larosa V, Fuchs P, Lo Schiavo F, Raffaello A, Rizzuto R, Costa A, Schwarzländer M, Szabò I. Plant Physiol. 2017 Feb;173(2):1355-1370. doi: 10.1104/pp.16.01359. Epub 2016 Dec 28.
251. Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics.
Zampieri S, Mammucari C, Romanello V, Barberi L, Pietrangelo L, Fusella A, Mosole S, Gherardi G, Höfer C, Löfler S, Sarabon N, Cvecka J, Krenn M, Carraro U, Kern H, Protasi F, Musarò A, Sandri M, Rizzuto R. Physiol Rep. 2016 Dec;4(24):e13005. doi: 10.14814/phy2.13005. PMID: 28039397 Free PMC article.
250. A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca2+ Uptake Machinery of Skeletal Muscle.
Vecellio Reane D, Vallese F, Checchetto V, Acquasaliente L, Butera G, De Filippis V, Szabò I, Zanotti G, Rizzuto R, Raffaello A. Mol Cell. 2016 Nov 17;64(4):760-773. doi: 10.1016/j.molcel.2016.10.001. Epub 2016 Nov 3.
249. Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.
Raffaello A, Mammucari C, Gherardi G, Rizzuto R. Trends Biochem Sci. 2016 Dec;41(12):1035-1049. doi: 10.1016/j.tibs.2016.09.001. Epub 2016 Sep 28.
248. The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria.
König T, Tröder SE, Bakka K, Korwitz A, Richter-Dennerlein R, Lampe PA, Patron M, Mühlmeister M, Guerrero-Castillo S, Brandt U, Decker T, Lauria I, Paggio A, Rizzuto R, Rugarli EI, De Stefani D, Langer T. Mol Cell. 2016 Oct 6;64(1):148-162. doi: 10.1016/j.molcel.2016.08.020. Epub 2016 Sep 15.
247. FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria.
Doghman-Bouguerra M, Granatiero V, Sbiera S, Sbiera I, Lacas-Gervais S, Brau F, Fassnacht M, Rizzuto R, Lalli E. EMBO Rep. 2016 Sep;17(9):1264-80. doi: 10.15252/embr.201541504. Epub 2016 Jul 11.
246. Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signalling.
Gregianin E, Pallafacchina G, Zanin S, Crippa V, Rusmini P, Poletti A, Fang M, Li Z, Diano L, Petrucci A, Lispi L, Cavallaro T, Fabrizi GM, Muglia M, Boaretto F, Vettori A, Rizzuto R, Mostacciuolo ML, Vazza G. Hum Mol Genet. 2016 Sep 1;25(17):3741-3753. doi: 10.1093/hmg/ddw220. Epub 2016 Jul 8.
245. Enjoy the Trip: Calcium in Mitochondria Back and Forth.
De Stefani D, Rizzuto R, Pozzan T. Annu Rev Biochem. 2016 Jun 2;85:161-92. doi: 10.1146/annurev-biochem-060614-034216. Epub 2016 May 4. PMID: 27145841 Review.
244. The mitochondrial calcium uniporter regulates breast cancer progression via HIF-1α.
Tosatto A, Sommaggio R, Kummerow C, Bentham RB, Blacker TS, Berecz T, Duchen MR, Rosato A, Bogeski I, Szabadkai G, Rizzuto R, Mammucari C. EMBO Mol Med. 2016 May 2;8(5):569-85. doi: 10.15252/emmm.201606255. Print 2016 May.
243. Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association.
Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn GW 2nd, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ; American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology. Circ Res. 2016 Jun 10;118(12):1960-91. doi: 10.1161/RES.0000000000000104. Epub 2016 Apr 28.
242. Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter.
Mammucari C, Raffaello A, Vecellio Reane D, Rizzuto R. Biochim Biophys Acta. 2016 Oct;1863(10):2457-64. doi: 10.1016/j.bbamcr.2016.03.006. Epub 2016 Mar 8.
241. Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase.
Granatiero V, Giorgio V, Calì T, Patron M, Brini M, Bernardi P, Tiranti V, Zeviani M, Pallafacchina G, De Stefani D, Rizzuto R. Cell Death Differ. 2016 Feb;23(2):231-41. doi: 10.1038/cdd.2015.84. Epub 2015 Jul 24.
240. Treatment by Therapeutic Magnetic Resonance (TMR™) increases fibroblastic activity and keratinocyte differentiation in an in vitro model of 3D artificial skin.
Ferroni L, Bellin G, Emer V, Rizzuto R, Isola M, Gardin C, Zavan B. J Tissue Eng Regen Med. 2017 May;11(5):1332-1342. doi: 10.1002/term.2031. Epub 2015 Jun 5.
239. Gene expression changes of single skeletal muscle fibers in response to modulation of the mitochondrial calcium uniporter (MCU).
Chemello F, Mammucari C, Gherardi G, Rizzuto R, Lanfranchi G, Cagnin S. Genom Data. 2015 May 30;5:64-7. doi: 10.1016/j.gdata.2015.05.023. eCollection 2015 Sep.
238. Structure and function of the mitochondrial calcium uniporter complex.
De Stefani D, Patron M, Rizzuto R. Biochim Biophys Acta. 2015 Sep;1853(9):2006-11. doi: 10.1016/j.bbamcr.2015.04.008. Epub 2015 Apr 18.
237. Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.
Medina DL, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, Montefusco S, Scotto-Rosato A, Prezioso C, Forrester A, Settembre C, Wang W, Gao Q, Xu H, Sandri M, Rizzuto R, De Matteis MA, Ballabio A. Nat Cell Biol. 2015 Mar;17(3):288-99. doi: 10.1038/ncb3114.
236. The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo.
Mammucari C, Gherardi G, Zamparo I, Raffaello A, Boncompagni S, Chemello F, Cagnin S, Braga A, Zanin S, Pallafacchina G, Zentilin L, Sandri M, De Stefani D, Protasi F, Lanfranchi G, Rizzuto R. Cell Rep. 2015 Mar 3;10(8):1269-79. doi: 10.1016/j.celrep.2015.01.056. Epub 2015 Feb 26.
235. p53 at the endoplasmic reticulum regulates apoptosis in a Ca2+-dependent manner.
Giorgi C, Bonora M, Sorrentino G, Missiroli S, Poletti F, Suski JM, Galindo Ramirez F, Rizzuto R, Di Virgilio F, Zito E, Pandolfi PP, Wieckowski MR, Mammano F, Del Sal G, Pinton P. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1779-84. doi: 10.1073/pnas.1410723112. Epub 2015 Jan 26.
234. Molecular diversity and pleiotropic role of the mitochondrial calcium uniporter.
Murgia M, Rizzuto R. Cell Calcium. 2015 Jul;58(1):11-7. doi: 10.1016/j.ceca.2014.11.001. Epub 2014 Nov 13.
233. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19.
232. Erratum to "Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock" [Mol Metab 3 (2014) 29-41].
Dyar KA, Ciciliot S, Wright LE, Biensø RS, Malagoli Tagliazucchi G, Patel VR, Forcato M, Peña-Paz MI, Gudiksen A, Solagna F, Albiero M, Moretti I, Eckel-Mahan KL, Baldi P, Sassone-Corsi P, Rizzuto R, Bicciato S, Pilegaard H, Blaauw B, Schiaffino S. Mol Metab. 2014 Sep 16;3(9):857. doi: 10.1016/j.molmet.2014.09.002. eCollection 2014 Dec.
231. Altered dopamine homeostasis differentially affects mitochondrial voltage-dependent anion channels turnover.
Alberio T, Mammucari C, D'Agostino G, Rizzuto R, Fasano M. Biochim Biophys Acta. 2014 Sep;1842(9):1816-22. doi: 10.1016/j.bbadis.2014.06.033. Epub 2014 Jul 3.
230. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter.
O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. Antioxid Redox Signal. 2014 Aug 20;21(6):863-79. doi: 10.1089/ars.2013.5394. Epub 2014 Jun 25.
229. Molecular control of mitochondrial calcium uptake.
De Stefani D, Rizzuto R. Biochem Biophys Res Commun. 2014 Jul 11;449(4):373-6. doi: 10.1016/j.bbrc.2014.04.142. Epub 2014 Apr 30.
228. Toll-like receptors hit calcium.
De Bernard M, Rizzuto R. EMBO Rep. 2014 May;15(5):468-9. doi: 10.1002/embr.201438685. Epub 2014 Apr 1. PMID: 24692506 Free PMC article.
227. MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.
Patron M, Checchetto V, Raffaello A, Teardo E, Vecellio Reane D, Mantoan M, Granatiero V, Szabò I, De Stefani D, Rizzuto R. Mol Cell. 2014 Mar 6;53(5):726-37. doi: 10.1016/j.molcel.2014.01.013. Epub 2014 Feb 20.
226. Measuring baseline Ca(2+) levels in subcellular compartments using genetically engineered fluorescent indicators.
Hill JM, De Stefani D, Jones AW, Ruiz A, Rizzuto R, Szabadkai G. Methods Enzymol. 2014;543:47-72. doi: 10.1016/B978-0-12-801329-8.00003-9.
225. Using targeted variants of aequorin to measure Ca2+ levels in intracellular organelles.
Granatiero V, Patron M, Tosatto A, Merli G, Rizzuto R. Cold Spring Harb Protoc. 2014 Jan 1;2014(1):86-93. doi: 10.1101/pdb.prot072843.
224. The use of aequorin and its variants for Ca2+ measurements.
Granatiero V, Patron M, Tosatto A, Merli G, Rizzuto R. Cold Spring Harb Protoc. 2014 Jan 1;2014(1):9-16. doi: 10.1101/pdb.top066118.
223. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.
Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R; UK10K Consortium, Duchen MR, Muntoni F, Sheridan E. Nat Genet. 2014 Feb;46(2):188-93. doi: 10.1038/ng.2851. Epub 2013 Dec 15.
222. Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research.
Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB, Fujita T, Gaetani R, Giacca M, Hasenfuß G, Heymans S, Leite-Moreira AF, Linke WA, Linz D, Lyon A, Mamas MA, Orešič M, Papp Z, Pedrazzini T, Piepoli M, Prosser B, Rizzuto R, Tarone G, Tian R, van Craenenbroeck E, van Rooij E, Wai T, Weiss G, Maack C. Eur J Heart Fail. 2014 Jan;16(1):6-14. doi: 10.1002/ejhf.10. Epub 2013 Dec 14.
221. Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production.
Rossato M, Granzotto M, Macchi V, Porzionato A, Petrelli L, Calcagno A, Vencato J, De Stefani D, Silvestrin V, Rizzuto R, Bassetto F, De Caro R, Vettor R. Mol Cell Endocrinol. 2014 Mar 5;383(1-2):137-46. doi: 10.1016/j.mce.2013.12.005. Epub 2013 Dec 14.
220. Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.
Dyar KA, Ciciliot S, Wright LE, Biensø RS, Tagliazucchi GM, Patel VR, Forcato M, Paz MI, Gudiksen A, Solagna F, Albiero M, Moretti I, Eckel-Mahan KL, Baldi P, Sassone-Corsi P, Rizzuto R, Bicciato S, Pilegaard H, Blaauw B, Schiaffino S. Mol Metab. 2013 Oct 23;3(1):29-41. doi: 10.1016/j.molmet.2013.10.005. eCollection 2014 Feb.
219. Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes.
Bonora M, Giorgi C, Bononi A, Marchi S, Patergnani S, Rimessi A, Rizzuto R, Pinton P. Nat Protoc. 2013 Nov;8(11):2105-18. doi: 10.1038/nprot.2013.127. Epub 2013 Oct 10.
218. The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. Raffaello A, De Stefani D, Sabbadin D, Teardo E, Merli G, Picard A, Checchetto V, Moro S, Szabò I, Rizzuto R. EMBO J. 2013 Aug 28;32(17):2362-76. doi: 10.1038/emboj.2013.157. Epub 2013 Jul 30.
217. Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway.
Sandri M, Barberi L, Bijlsma AY, Blaauw B, Dyar KA, Milan G, Mammucari C, Meskers CG, Pallafacchina G, Paoli A, Pion D, Roceri M, Romanello V, Serrano AL, Toniolo L, Larsson L, Maier AB, Muñoz-Cánoves P, Musarò A, Pende M, Reggiani C, Rizzuto R, Schiaffino S. Biogerontology. 2013 Jun;14(3):303-23. doi: 10.1007/s10522-013-9432-9. Epub 2013 May 19.
216. Kαλóς και Aγαθóς: how mitochondrial beauty translates into biological virtue.
Szabadkai G, Rizzuto R. Curr Opin Cell Biol. 2013 Aug;25(4):477-82. doi: 10.1016/j.ceb.2013.03.006. Epub 2013 May 14.
215. The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles.
Patron M, Raffaello A, Granatiero V, Tosatto A, Merli G, De Stefani D, Wright L, Pallafacchina G, Terrin A, Mammucari C, Rizzuto R. J Biol Chem. 2013 Apr 12;288(15):10750-8. doi: 10.1074/jbc.R112.420752. Epub 2013 Feb 11.
214. Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25.
Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrà F, Giorgi C, De Marchi E, Poletti F, Gafà R, Lanza G, Negrini M, Rizzuto R, Pinton P. Curr Biol. 2013 Jan 7;23(1):58-63. doi: 10.1016/j.cub.2012.11.026. Epub 2012 Dec 13.
213. Frequency-dependent mitochondrial Ca(2+) accumulation regulates ATP synthesis in pancreatic β cells.
Tarasov AI, Semplici F, Li D, Rizzuto R, Ravier MA, Gilon P, Rutter GA. Pflugers Arch. 2013 Apr;465(4):543-54. doi: 10.1007/s00424-012-1177-9. Epub 2012 Nov 14.
212. Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-β (CaMKK-β).
Ghislat G, Patron M, Rizzuto R, Knecht E. J Biol Chem. 2012 Nov 9;287(46):38625-36. doi: 10.1074/jbc.M112.365767. Epub 2012 Oct 1.
211. Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics.
Konstantinidis K, Lederer WJ, Rizzuto R, Kitsis RN. Circ Res. 2012 Sep 14;111(7):821-3. doi: 10.1161/CIRCRESAHA.112.277269.
210. Mitochondrial 'flashes': a radical concept repHined.
Schwarzländer M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Müller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ. Trends Cell Biol. 2012 Oct;22(10):503-8. doi: 10.1016/j.tcb.2012.07.007. Epub 2012 Aug 20.
209. Mitochondria as sensors and regulators of calcium signalling. Rizzuto R, De Stefani D, Raffaello A, Mammucari C. Nat Rev Mol Cell Biol. 2012 Sep;13(9):566-78. doi: 10.1038/nrm3412. Epub 2012 Aug 1.
208. Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes.
Drago I, De Stefani D, Rizzuto R, Pozzan T. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12986-91. doi: 10.1073/pnas.1210718109. Epub 2012 Jul 20.
207. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress.
Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, Piette J, Linehan C, Gupta S, Samali A, Agostinis P. Cell Death Differ. 2012 Nov;19(11):1880-91. doi: 10.1038/cdd.2012.74. Epub 2012 Jun 15.
206. Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation.
Maltecca F, De Stefani D, Cassina L, Consolato F, Wasilewski M, Scorrano L, Rizzuto R, Casari G. Hum Mol Genet. 2012 Sep 1;21(17):3858-70. doi: 10.1093/hmg/dds214. Epub 2012 Jun 7.
205. The mitochondrial Ca(2+) uniporter.
Raffaello A, De Stefani D, Rizzuto R. Cell Calcium. 2012 Jul;52(1):16-21. doi: 10.1016/j.ceca.2012.04.006. Epub 2012 Jun 4.
204. Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.
Nowikovsky K, Pozzan T, Rizzuto R, Scorrano L, Bernardi P. J Gen Physiol. 2012 Jun;139(6):445-54. doi: 10.1085/jgp.201110757.
203. Copper and bezafibrate cooperate to rescue cytochrome c oxidase deficiency in cells of patients with SCO2 mutations.
Casarin A, Giorgi G, Pertegato V, Siviero R, Cerqua C, Doimo M, Basso G, Sacconi S, Cassina M, Rizzuto R, Brosel S, M Davidson M, Dimauro S, Schon EA, Clementi M, Trevisson E, Salviati L. Orphanet J Rare Dis. 2012 Apr 19;7:21. doi: 10.1186/1750-1172-7-21.
202. The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells.
Rimessi A, Zecchini E, Siviero R, Giorgi C, Leo S, Rizzuto R, Pinton P. Cell Cycle. 2012 Mar 1;11(5):1040-8. doi: 10.4161/cc.11.5.19520. Epub 2012 Mar 1.
201. Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle.
Chang NC, Nguyen M, Bourdon J, Risse PA, Martin J, Danialou G, Rizzuto R, Petrof BJ, Shore GC. Hum Mol Genet. 2012 May 15;21(10):2277-87. doi: 10.1093/hmg/dds048. Epub 2012 Feb 15.
200. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis.
Rojas-Rivera D, Armisén R, Colombo A, Martínez G, Eguiguren AL, Díaz A, Kiviluoto S, Rodríguez D, Patron M, Rizzuto R, Bultynck G, Concha ML, Sierralta J, Stutzin A, Hetz C. Cell Death Differ. 2012 Jun;19(6):1013-26. doi: 10.1038/cdd.2011.189. Epub 2012 Jan 13.
199. The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.
Tarasov AI, Semplici F, Ravier MA, Bellomo EA, Pullen TJ, Gilon P, Sekler I, Rizzuto R, Rutter GA. PLoS One. 2012;7(7):e39722. doi: 10.1371/journal.pone.0039722. Epub 2012 Jul 19.
198. Ero1α regulates Ca(2+) fluxes at the endoplasmic reticulum-mitochondria interface (MAM).
Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R, Sitia R. Antioxid Redox Signal. 2012 May 15;16(10):1077-87. doi: 10.1089/ars.2011.4004. Epub 2011 Oct 19.
197. VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.
De Stefani D, Bononi A, Romagnoli A, Messina A, De Pinto V, Pinton P, Rizzuto R. Cell Death Differ. 2012 Feb;19(2):267-73. doi: 10.1038/cdd.2011.92. Epub 2011 Jul 1.
196. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. De Stefani D, Raffaello A, Teardo E, Szabò I, Rizzuto R. Nature. 2011 Jun 19;476(7360):336-40. doi: 10.1038/nature10230.
195. Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure.
Giorgi C, Romagnoli A, Agnoletto C, Bergamelli L, Sorrentino G, Brini M, Pozzan T, Meldolesi J, Pinton P, Rizzuto R. BMC Cell Biol. 2011 Jun 9;12:27. doi: 10.1186/1471-2121-12-27.
Molecules and roles of mitochondrial calcium signaling.
Mammucari C, Patron M, Granatiero V, Rizzuto R. Biofactors. 2011 May-Jun;37(3):219-27. doi: 10.1002/biof.160. Epub 2011 Jun 14.
194. PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.
Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP. Science. 2010 Nov 26;330(6008):1247-51. doi: 10.1126/science.1189157. Epub 2010 Oct 28.
193. Mitochondrial longevity pathways.
Raffaello A, Rizzuto R. Biochim Biophys Acta. 2011 Jan;1813(1):260-8. doi: 10.1016/j.bbamcr.2010.10.007. Epub 2010 Oct 13.
192. Signaling pathways in mitochondrial dysfunction and aging.
Mammucari C, Rizzuto R. Mech Ageing Dev. 2010 Jul-Aug;131(7-8):536-43. doi: 10.1016/j.mad.2010.07.003. Epub 2010 Jul 24.
191. Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency.
Mbaya E, Oulès B, Caspersen C, Tacine R, Massinet H, Pennuto M, Chrétien D, Munnich A, Rötig A, Rizzuto R, Rutter GA, Paterlini-Bréchot P, Chami M. Cell Death Differ. 2010 Dec;17(12):1855-66. doi: 10.1038/cdd.2010.51. Epub 2010 May 21.
190. The p13 protein of human T cell leukemia virus type 1 (HTLV-1) modulates mitochondrial membrane potential and calcium uptake.
Biasiotto R, Aguiari P, Rizzuto R, Pinton P, D'Agostino DM, Ciminale V. Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):945-51. doi: 10.1016/j.bbabio.2010.02.023. Epub 2010 Feb 25.
189. NF-kappaB activation is required for apoptosis in fibrocystin/polyductin-depleted kidney epithelial cells.
Mangolini A, Bogo M, Durante C, Borgatti M, Gambari R, Harris PC, Rizzuto R, Pinton P, Aguiari G, del Senno L. Apoptosis. 2010 Jan;15(1):94-104. doi: 10.1007/s10495-009-0426-7.
188. Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation.
Ferrari D, Pinton P, Campanella M, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R. Biochem Biophys Res Commun. 2010 Jan 1;391(1):575-81. doi: 10.1016/j.bbrc.2009.11.101. Epub 2009 Nov 24.
187. The origin of intermuscular adipose tissue and its pathophysiological implications.
Vettor R, Milan G, Franzin C, Sanna M, De Coppi P, Rizzuto R, Federspil G. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E987-98. doi: 10.1152/ajpendo.00229.2009. Epub 2009 Sep 8.
186. Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis.
Rimessi A, Marchi S, Fotino C, Romagnoli A, Huebner K, Croce CM, Pinton P, Rizzuto R. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12753-8. doi: 10.1073/pnas.0906484106. Epub 2009 Jul 21.
185. Structural and functional link between the mitochondrial network and the endoplasmic reticulum.
Giorgi C, De Stefani D, Bononi A, Rizzuto R, Pinton P. Int J Biochem Cell Biol. 2009 Oct;41(10):1817-27. doi: 10.1016/j.biocel.2009.04.010. Epub 2009 Apr 21.
184. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malomi W, Marine JC, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Cell Death Differ. 2009 Aug;16(8):1093-107. doi: 10.1038/cdd.2009.44. Epub 2009 Apr 17.
183. Ca(2+) transfer from the ER to mitochondria: when, how and why.
Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R, Zecchini E, Pinton P. Biochim Biophys Acta. 2009 Nov;1787(11):1342-51. doi: 10.1016/j.bbabio.2009.03.015. Epub 2009 Mar 31.
182. Age-related changes in levels of p66Shc and serine 36-phosphorylated p66Shc in organs and mouse tissues.
Lebiedzinska M, Duszynski J, Rizzuto R, Pinton P, Wieckowski MR. Arch Biochem Biophys. 2009 Jun 1;486(1):73-80. doi: 10.1016/j.abb.2009.03.007. Epub 2009 Mar 25.
181. Mitochondria: from basic biology to cardiovascular disease.
Murphy E, Bers D, Rizzuto R. J Mol Cell Cardiol. 2009 Jun;46(6):765-6. doi: 10.1016/j.yjmcc.2009.03.004. Epub 2009 Mar 14.
180. Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling.
Murgia M, Giorgi C, Pinton P, Rizzuto R. J Mol Cell Cardiol. 2009 Jun;46(6):781-8. doi: 10.1016/j.yjmcc.2009.03.003. Epub 2009 Mar 12.
179. Deficiency of polycystic kidney disease-1 gene (PKD1) expression increases A(3) adenosine receptors in human renal cells: implications for cAMP-dependent signalling and proliferation of PKD1-mutated cystic cells.
Aguiari G, Varani K, Bogo M, Mangolini A, Vincenzi F, Durante C, Gessi S, Sacchetto V, Catizone L, Harris P, Rizzuto R, Borea PA, Del Senno L. Biochim Biophys Acta. 2009 Jun;1792(6):531-40. doi: 10.1016/j.bbadis.2009.03.001. Epub 2009 Mar 11.
178. Mitochondria, calcium and cell death: a deadly triad in neurodegeneration.
Celsi F, Pizzo P, Brini M, Leo S, Fotino C, Pinton P, Rizzuto R. Biochim Biophys Acta. 2009 May;1787(5):335-44. doi: 10.1016/j.bbabio.2009.02.021. Epub 2009 Mar 4.
177. Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis.
Adinolfi E, Callegari MG, Cirillo M, Pinton P, Giorgi C, Cavagna D, Rizzuto R, Di Virgilio F. J Biol Chem. 2009 Apr 10;284(15):10120-8. doi: 10.1074/jbc.M805805200. Epub 2009 Feb 9.
176. MAM: more than just a housekeeper.
Hayashi T, Rizzuto R, Hajnoczky G, Su TP. Trends Cell Biol. 2009 Feb;19(2):81-8. doi: 10.1016/j.tcb.2008.12.002. Epub 2009 Jan 12.
175. Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.
Saotome M, Safiulina D, Szabadkai G, Das S, Fransson A, Aspenstrom P, Rizzuto R, Hajnóczky G. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20728-33. doi: 10.1073/pnas.0808953105. Epub 2008 Dec 19.
174. Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress.
Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini-Bréchot P. Mol Cell. 2008 Dec 5;32(5):641-51. doi: 10.1016/j.molcel.2008.11.014
173. The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2+) load upon cell stimulation by inhibiting Ca(2+) efflux from the organelle.
Leo S, Szabadkai G, Rizzuto R. Ann N Y Acad Sci. 2008 Dec;1147:264-74. doi: 10.1196/annals.1427.019.
172. Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis.
Pinton P, Giorgi C, Siviero R, Zecchini E, Rizzuto R. Oncogene. 2008 Oct 27;27(50):6407-18. doi: 10.1038/onc.2008.308.
171. Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195.
Campanella M, Szabadkai G, Rizzuto R. Biochem Pharmacol. 2008 Dec 1;76(11):1628-36. doi: 10.1016/j.bcp.2008.09.034. Epub 2008 Oct 4.
170. Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli.
Marchi S, Rimessi A, Giorgi C, Baldini C, Ferroni L, Rizzuto R, Pinton P. Biochem Biophys Res Commun. 2008 Oct 31;375(4):501-5. doi: 10.1016/j.bbrc.2008.07.153. Epub 2008 Aug 22. 169. Imaging calcium dynamics using targeted recombinant aequorins. Pozzan T, Rizzuto R. CSH Protoc. 2008 Aug 1;2008:pdb.top26. doi: 10.1101/pdb.top26.
168. The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death.
Rimessi A, Giorgi C, Pinton P, Rizzuto R. Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):808-16. doi: 10.1016/j.bbabio.2008.05.449.
167. Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.
Vettor R, Granzotto M, De Stefani D, Trevellin E, Rossato M, Farina MG, Milan G, Pilon C, Nigro A, Federspil G, Vigneri R, Vitiello L, Rizzuto R, Baratta R, Frittitta L. J Clin Endocrinol Metab. 2008 Sep;93(9):3541-50. doi: 10.1210/jc.2007-2680. Epub 2008 Jun 26.
166. Regulation of autophagy by cytoplasmic p53.
Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G. Nat Cell Biol. 2008 Jun;10(6):676-87. doi: 10.1038/ncb1730. Epub 2008 May 4.
165. Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells.
Aguiari G, Trimi V, Bogo M, Mangolini A, Szabadkai G, Pinton P, Witzgall R, Harris PC, Borea PA, Rizzuto R, del Senno L. Cell Prolif. 2008 Jun;41(3):554-73. doi: 10.1111/j.1365-2184.2008.00529.x. Epub 2008 Apr 15.
164. Peroxisomes as novel players in cell calcium homeostasis.
Lasorsa FM, Pinton P, Palmieri L, Scarcia P, Rottensteiner H, Rizzuto R, Palmieri F. J Biol Chem. 2008 May 30;283(22):15300-8. doi: 10.1074/jbc.M800648200. Epub 2008 Mar 25.
163. Ca2+ signaling, mitochondria and cell death.
Giorgi C, Romagnoli A, Pinton P, Rizzuto R. Curr Mol Med. 2008 Mar;8(2):119-30. doi: 10.2174/156652408783769571
162. High glucose induces adipogenic differentiation of muscle-derived stem cells.
Aguiari P, Leo S, Zavan B, Vindigni V, Rimessi A, Bianchi K, Franzin C, Cortivo R, Rossato M, Vettor R, Abatangelo G, Pozzan T, Pinton P, Rizzuto R. Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1226-31. doi: 10.1073/pnas.0711402105. Epub 2008 Jan 22.
161. Mitochondrial calcium signalling: message of life and death.
Zecchini E, Siviero R, Giorgi C, Rizzuto R, Pinton P. Ital J Biochem. 2007 Dec;56(4):235-42.
160. Measurements of mitochondrial pH in cultured cortical neurons clarify contribution of mitochondrial pore to the mechanism of glutamate-induced delayed Ca2+ deregulation.
Bolshakov AP, Mikhailova MM, Szabadkai G, Pinelis VG, Brustovetsky N, Rizzuto R, Khodorov BI. Cell Calcium. 2008 Jun;43(6):602-14. doi: 10.1016/j.ceca.2007.10.005. Epub 2007 Nov 26.
159. p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria.
Pinton P, Rizzuto R. Cell Cycle. 2008 Feb 1;7(3):304-8. doi: 10.4161/cc.7.3.5360. Epub 2007 Nov 20.
158. The endogenous cannabinoid system stimulates glucose uptake in human fat cells via phosphatidylinositol 3-kinase and calcium-dependent mechanisms.
Pagano C, Pilon C, Calcagno A, Urbanet R, Rossato M, Milan G, Bianchi K, Rizzuto R, Bernante P, Federspil G, Vettor R. J Clin Endocrinol Metab. 2007 Dec;92(12):4810-9. doi: 10.1210/jc.2007-0768. Epub 2007 Sep 4.
157. Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis.
Biagioli M, Pifferi S, Ragghianti M, Bucci S, Rizzuto R, Pinton P. Cell Calcium. 2008 Feb;43(2):184-95. doi: 10.1016/j.ceca.2007.05.003. Epub 2007 Jun 22.
156. Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R. Science. 2007 Feb 2;315(5812):659-63. doi: 10.1126/science.1135380.
155. Regulation of autophagy by the inositol trisphosphate receptor.
Criollo A, Maiuri MC, Tasdemir E, Vitale I, Fiebig AA, Andrews D, Molgó J, Díaz J, Lavandero S, Harper F, Pierron G, di Stefano D, Rizzuto R, Szabadkai G, Kroemer G. Cell Death Differ. 2007 May;14(5):1029-39. doi: 10.1038/sj.cdd.4402099. Epub 2007 Jan 26.
154. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.
Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Bianchi K, Fehrenbacher N, Elling F, Rizzuto R, Mathiasen IS, Jäättelä M. Mol Cell. 2007 Jan 26;25(2):193-205. doi: 10.1016/j.molcel.2006.12.009.
153. Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice.
Dell'agnello C, Leo S, Agostino A, Szabadkai G, Tiveron C, Zulian A, Prelle A, Roubertoux P, Rizzuto R, Zeviani M. Hum Mol Genet. 2007 Feb 15;16(4):431-44. doi: 10.1093/hmg/ddl477. Epub 2007 Jan 8.
152. Differential recruitment of PKC isoforms in HeLa cells during redox stress.
Rimessi A, Rizzuto R, Pinton P. Cell Stress Chaperones. 2007 Winter;12(4):291-8. doi: 10.1379/csc-211.1.
151. Endoplasmic reticulum/mitochondria calcium cross-talk.
Romagnoli A, Aguiari P, De Stefani D, Leo S, Marchi S, Rimessi A, Zecchini E, Pinton P, Rizzuto R. Novartis Found Symp. 2007;287:122-31; discussion 131-9.
150. Biosensors for the detection of calcium and pH.
Pinton P, Rimessi A, Romagnoli A, Prandini A, Rizzuto R. Methods Cell Biol. 2007;80:297-325. doi: 10.1016/S0091-679X(06)80015-4.
149. Chaperones as parts of organelle networks.
Szabadkai G, Rizzuto R. Adv Exp Med Biol. 2007;594:64-77. doi: 10.1007/978-0-387-39975-1_7.
148. Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.
Szabadkai G, Bianchi K, Várnai P, De Stefani D, Wieckowski MR, Cavagna D, Nagy AI, Balla T, Rizzuto R. J Cell Biol. 2006 Dec 18;175(6):901-11. doi: 10.1083/jcb.200608073.
147. Sphingosine 1-phosphate receptors modulate intracellular Ca2+ homeostasis.
Rapizzi E, Donati C, Cencetti F, Pinton P, Rizzuto R, Bruni P. Biochem Biophys Res Commun. 2007 Feb 9;353(2):268-74. doi: 10.1016/j.bbrc.2006.12.010. Epub 2006 Dec 11.
146. Polycystin-1 promotes PKCalpha-mediated NF-kappaB activation in kidney cells.
Banzi M, Aguiari G, Trimi V, Mangolini A, Pinton P, Witzgall R, Rizzuto R, del Senno L. Biochem Biophys Res Commun. 2006 Nov 17;350(2):257-62. doi: 10.1016/j.bbrc.2006.09.042. Epub 2006 Sep 18.
145. Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA.
Poncet D, Pauleau AL, Szabadkai G, Vozza A, Scholz SR, Le Bras M, Brière JJ, Jalil A, Le Moigne R, Brenner C, Hahn G, Wittig I, Schägger H, Lemaire C, Bianchi K, Souquère S, Pierron G, Rustin P, Goldmacher VS, Rizzuto R, Palmieri F, Kroemer G. J Cell Biol. 2006 Sep 25;174(7):985-96. doi: 10.1083/jcb.200604069. Epub 2006 Sep 18.
144. Overexpression of adenine nucleotide translocase reduces Ca2+ signal transmission between the ER and mitochondria.
Wieckowski MR, Szabadkai G, Wasilewski M, Pinton P, Duszyński J, Rizzuto R. Biochem Biophys Res Commun. 2006 Sep 22;348(2):393-9. doi: 10.1016/j.bbrc.2006.07.072. Epub 2006 Jul 25.
143. Intracellular evaluation of ER targeting elucidates a mild form of inherited coagulation deficiency.
Rizzotto L, Pinotti M, Pinton P, Rizzuto R, Bernardi F. Mol Med. 2006 Jul-Aug;12(7-8):137-42. doi: 10.2119/2005-00040.Rizzotto.
142. Intracellular readthrough of nonsense mutations by aminoglycosides in coagulation factor VII.
Pinotti M, Rizzotto L, Pinton P, Ferraresi P, Chuansumrit A, Charoenkwan P, Marchetti G, Rizzuto R, Mariani G, Bernardi F; International Factor VII Deficiency Study Group. J Thromb Haemost. 2006 Jun;4(6):1308-14. doi: 10.1111/j.1538-7836.2006.01915.x.
141. Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum.
Pinton P, Rizzuto R. Cell Death Differ. 2006 Aug;13(8):1409-18. doi: 10.1038/sj.cdd.4401960. Epub 2006 May 26.
140. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.
Pulina MV, Rizzuto R, Brini M, Carafoli E. J Biol Chem. 2006 Jul 14;281(28):19645-54. doi: 10.1074/jbc.M602033200. Epub 2006 May 5.
139. Mitochondrial dynamics and Ca2+ signaling.
Szabadkai G, Simoni AM, Bianchi K, De Stefani D, Leo S, Wieckowski MR, Rizzuto R. Biochim Biophys Acta. 2006 May-Jun;1763(5-6):442-9. doi: 10.1016/j.bbamcr.2006.04.002. Epub 2006 Apr 20.
138. Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1alpha.
Bianchi K, Vandecasteele G, Carli C, Romagnoli A, Szabadkai G, Rizzuto R. Cell Death Differ. 2006 Apr;13(4):586-96. doi: 10.1038/sj.cdd.4401784.
137. Tissue transglutaminase (TG2) protects cardiomyocytes against ischemia/reperfusion injury by regulating ATP synthesis.
Szondy Z, Mastroberardino PG, Váradi J, Farrace MG, Nagy N, Bak I, Viti I, Wieckowski MR, Melino G, Rizzuto R, Tósaki A, Fesus L, Piacentini M. Cell Death Differ. 2006 Oct;13(10):1827-9. doi: 10.1038/sj.cdd.4401889. Epub 2006 Mar 10.
136. HIV-1 protease inhibitors and cytomegalovirus vMIA induce mitochondrial fragmentation without triggering apoptosis.
Roumier T, Szabadkai G, Simoni AM, Perfettini JL, Paulau AL, Castedo M, Métivier D, Badley A, Rizzuto R, Kroemer G. Cell Death Differ. 2006 Feb;13(2):348-51. doi: 10.1038/sj.cdd.4401750.
135. Microdomains of intracellular Ca2+: molecular determinants and functional consequences.
Rizzuto R, Pozzan T. Physiol Rev. 2006 Jan;86(1):369-408. doi: 10.1152/physrev.00004.2005.
134. Inhibitory interaction of the 14-3-3{epsilon} protein with isoform 4 of the plasma membrane Ca(2+)-ATPase pump. Rimessi A, Coletto L, Pinton P, Rizzuto R, Brini M, Carafoli E. J Biol Chem. 2005 Nov 4;280(44):37195-203. doi: 10.1074/jbc.M504921200. Epub 2005 Aug 26.
133. Mitochondrial calcium signalling in cell death.
Leo S, Bianchi K, Brini M, Rizzuto R. FEBS J. 2005 Aug;272(16):4013-22. doi: 10.1111/j.1742-4658.2005.04855.x.
132. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis.
Giorgio M, Migliaccio E, Orsini F, Paolucci D, Moroni M, Contursi C, Pelliccia G, Luzi L, Minucci S, Marcaccio M, Pinton P, Rizzuto R, Bernardi P, Paolucci F, Pelicci PG. Cell. 2005 Jul 29;122(2):221-33. doi: 10.1016/j.cell.2005.05.011.
131. Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion.
Benali-Furet NL, Chami M, Houel L, De Giorgi F, Vernejoul F, Lagorce D, Buscail L, Bartenschlager R, Ichas F, Rizzuto R, Paterlini-Bréchot P. Oncogene. 2005 Jul 21;24(31):4921-33. doi: 10.1038/sj.onc.1208673
130. The Golgi Ca2+-ATPase KlPmr1p function is required for oxidative stress response by controlling the expression of the heat-shock element HSP60 in Kluyveromyces lactis.
Uccelletti D, Farina F, Pinton P, Goffrini P, Mancini P, Talora C, Rizzuto R, Palleschi C. Mol Biol Cell. 2005 Oct;16(10):4636-47. doi: 10.1091/mbc.e05-02-0138. Epub 2005 Jul 19
129. A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion.
Pellegatti P, Falzoni S, Pinton P, Rizzuto R, Di Virgilio F. Mol Biol Cell. 2005 Aug;16(8):3659-65. doi: 10.1091/mbc.e05-03-0222. Epub 2005 Jun 8.
128. Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth.
Adinolfi E, Callegari MG, Ferrari D, Bolognesi C, Minelli M, Wieckowski MR, Pinton P, Rizzuto R, Di Virgilio F. Mol Biol Cell. 2005 Jul;16(7):3260-72. doi: 10.1091/mbc.e04-11-1025. Epub 2005 May 18.
127. Calcium dynamics in catecholamine-containing secretory vesicles.
Moreno A, Lobatón CD, Santodomingo J, Vay L, Hernández-SanMiguel E, Rizzuto R, Montero M, Alvarez J. Cell Calcium. 2005 Jun;37(6):555-64. doi: 10.1016/j.ceca.2005.02.002. Epub 2005 Apr 8.
126. Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism.
Gallo A, Ceolotto G, Pinton P, Iori E, Murphy E, Rutter GA, Rizzuto R, Semplicini A, Avogaro A. Diabetes. 2005 Apr;54(4):1123-31. doi: 10.2337/diabetes.54.4.1123.
125. Aequorin chimeras as valuable tool in the measurement of Ca2+ concentration during cadmium injury.
Biagioli M, Pinton P, Scudiero R, Ragghianti M, Bucci S, Rizzuto R. Toxicology. 2005 Mar 30;208(3):389-98. doi: 10.1016/j.tox.2004.11.038. PMID: 15695024
124. Expression, pharmacological profile, and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells using a novel selective antagonist radioligand, [3H]MRE 2029-F20.
Gessi S, Varani K, Merighi S, Cattabriga E, Pancaldi C, Szabadkai Y, Rizzuto R, Klotz KN, Leung E, Mac Lennan S, Baraldi PG, Borea PA. Mol Pharmacol. 2005 Jun;67(6):2137-47. doi: 10.1124/mol.104.009225. Epub 2005 Mar 23.
123. Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction.
Cipriani G, Rapizzi E, Vannacci A, Rizzuto R, Moroni F, Chiarugi A. J Biol Chem. 2005 Apr 29;280(17):17227-34. doi: 10.1074/jbc.M414526200. Epub 2005 Mar 4.
122. Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity.
Bano D, Young KW, Guerin CJ, Lefeuvre R, Rothwell NJ, Naldini L, Rizzuto R, Carafoli E, Nicotera P. Cell. 2005 Jan 28;120(2):275-85. doi: 10.1016/j.cell.2004.11.049. PMID: 15680332 Free article.
121. pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant.
Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M. Biochem Biophys Res Commun. 2005 Jan 28;326(4):799-804. doi: 10.1016/j.bbrc.2004.11.105.
120. The cytoplasmic C-terminus of polycystin-1 increases cell proliferation in kidney epithelial cells through serum-activated and Ca(2+)-dependent pathway(s).
Manzati E, Aguiari G, Banzi M, Manzati M, Selvatici R, Falzarano S, Maestri I, Pinton P, Rizzuto R, del Senno L. Exp Cell Res. 2005 Apr 1;304(2):391-406. doi: 10.1016/j.yexcr.2004.10.023. Epub 2004 Dec 15.
119. Calcium and mitochondria: mechanisms and functions of a troubled relationship.
Bianchi K, Rimessi A, Prandini A, Szabadkai G, Rizzuto R. Biochim Biophys Acta. 2004 Dec 6;1742(1-3):119-31. doi: 10.1016/j.bbamcr.2004.09.015.
118. Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments.
Missiaen L, Van Acker K, Van Baelen K, Raeymaekers L, Wuytack F, Parys JB, De Smedt H, Vanoevelen J, Dode L, Rizzuto R, Callewaert G. Cell Calcium. 2004 Dec;36(6):479-87. doi: 10.1016/j.ceca.2004.04.007.
117. Chondrocyte protein with a poly-proline region (CHPPR) is a novel mitochondrial protein and promotes mitochondrial fission.
Tonachini L, Monticone M, Puri C, Tacchetti C, Pinton P, Rizzuto R, Cancedda R, Tavella S, Castagnola P. J Cell Physiol. 2004 Dec;201(3):470-82. doi: 10.1002/jcp.20126.
116. Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region.
Chami M, Prandini A, Campanella M, Pinton P, Szabadkai G, Reed JC, Rizzuto R. J Biol Chem. 2004 Dec 24;279(52):54581-9. doi: 10.1074/jbc.M409663200. Epub 2004 Oct 12.
115. Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis.
Szabadkai G, Simoni AM, Chami M, Wieckowski MR, Youle RJ, Rizzuto R. Mol Cell. 2004 Oct 8;16(1):59-68. doi: 10.1016/j.molcel.2004.09.026. 114. Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood? Szabadkai G, Rizzuto R. FEBS Lett. 2004 Jun 1;567(1):111-5. doi: 10.1016/j.febslet.2004.04.059.
113. Long-term modulation of mitochondrial Ca2+ signals by protein kinase C isozymes.
Pinton P, Leo S, Wieckowski MR, Di Benedetto G, Rizzuto R. J Cell Biol. 2004 Apr 26;165(2):223-32. doi: 10.1083/jcb.200311061. Epub 2004 Apr 19. 112. The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. Campanella M, de Jong AS, Lanke KW, Melchers WJ, Willems PH, Pinton P, Rizzuto R, van Kuppeveld FJ. J Biol Chem. 2004 Apr 30;279(18):18440-50. doi: 10.1074/jbc.M309494200. Epub 2004 Feb 19.
111. Flirting in little space: the ER/mitochondria Ca2+ liaison.
Rizzuto R, Duchen MR, Pozzan T. Sci STKE. 2004 Jan 13;2004(215):re1. doi: 10.1126/stke.2152004re1.
110. Mitochondrial Ca2+ homeostasis in health and disease.
Campanella M, Pinton P, Rizzuto R. Biol Res. 2004;37(4):653-60. doi: 10.4067/s0716-97602004000400022.
109. Lip reconstruction after ablation for skin malignancies.
Dupin C, Metzinger S, Rizzuto R. Clin Plast Surg. 2004 Jan;31(1):69-85. doi: 10.1016/s0094-1298(03)00118-4.
108. The collagen-mitochondria connection.
Rizzuto R. Nat Genet. 2003 Dec;35(4):300-1. doi: 10.1038/ng1203-300.
107. Calcium and apoptosis: facts and hypotheses.
Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, Di Virgilio F, Pozzan T. Oncogene. 2003 Nov 24;22(53):8619-27. doi: 10.1038/sj.onc.1207105.
106. Calcium mobilization from mitochondria in synaptic transmitter release.
Rizzuto R. J Cell Biol. 2003 Nov 10;163(3):441-3. doi: 10.1083/jcb.200309111.
105. Similar Ca(2+)-signaling properties in keratinocytes and in COS-1 cells overexpressing the secretory-pathway Ca(2+)-ATPase SPCA1.
Callewaert G, Parys JB, De Smedt H, Raeymaekers L, Wuytack F, Vanoevelen J, Van Baelen K, Simoni A, Rizzuto R, Missiaen L. Cell Calcium. 2003 Aug;34(2):157-62. doi: 10.1016/s0143-4160(03)00070-8.
104. Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells.
Lasorsa FM, Pinton P, Palmieri L, Fiermonte G, Rizzuto R, Palmieri F. J Biol Chem. 2003 Oct 3;278(40):38686-92. doi: 10.1074/jbc.M304988200. Epub 2003 Jul 8.
103. Looking forward to seeing calcium.
Rudolf R, Mongillo M, Rizzuto R, Pozzan T. Nat Rev Mol Cell Biol. 2003 Jul;4(7):579-86. doi: 10.1038/nrm1153.
102. The contribution of the SPCA1 Ca2+ pump to the Ca2+ accumulation in the Golgi apparatus of HeLa cells assessed via RNA-mediated interference.
Van Baelen K, Vanoevelen J, Callewaert G, Parys JB, De Smedt H, Raeymaekers L, Rizzuto R, Missiaen L, Wuytack F. Biochem Biophys Res Commun. 2003 Jun 27;306(2):430-6. doi: 10.1016/s0006-291x(03)00977-x.
101. Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein.
Chami M, Ferrari D, Nicotera P, Paterlini-Bréchot P, Rizzuto R. J Biol Chem. 2003 Aug 22;278(34):31745-55. doi: 10.1074/jbc.M304202200. Epub 2003 Jun 10.
100. When calcium goes wrong: genetic alterations of a ubiquitous signaling route.
Rizzuto R, Pozzan T. Nat Genet. 2003 Jun;34(2):135-41. doi: 10.1038/ng0603-135.
99. Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells.
Morelli A, Chiozzi P, Chiesa A, Ferrari D, Sanz JM, Falzoni S, Pinton P, Rizzuto R, Olson MF, Di Virgilio F. Mol Biol Cell. 2003 Jul;14(7):2655-64. doi: 10.1091/mbc.02-04-0061. Epub 2003 Apr 4.
98. Expression of polycystin-1 C-terminal fragment enhances the ATP-induced Ca2+ release in human kidney cells.
Aguiari G, Campanella M, Manzati E, Pinton P, Banzi M, Moretti S, Piva R, Rizzuto R, del Senno L. Biochem Biophys Res Commun. 2003 Feb 14;301(3):657-64. doi: 10.1016/s0006-291x(02)03011-5.
97. Mitochondrial Ca2+ uptake requires sustained Ca2+ release from the endoplasmic reticulum.
Szabadkai G, Simoni AM, Rizzuto R. J Biol Chem. 2003 Apr 25;278(17):15153-61. doi: 10.1074/jbc.M300180200. Epub 2003 Feb 13.
96. Bcl-2 and Bax modulate adenine nucleotide translocase activity.
Belzacq AS, Vieira HL, Verrier F, Vandecasteele G, Cohen I, Prévost MC, Larquet E, Pariselli F, Petit PX, Kahn A, Rizzuto R, Brenner C, Kroemer G. Cancer Res. 2003 Jan 15;63(2):541-6.
95. Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria.
Rapizzi E, Pinton P, Szabadkai G, Wieckowski MR, Vandecasteele G, Baird G, Tuft RA, Fogarty KE, Rizzuto R. J Cell Biol. 2002 Nov 25;159(4):613-24. doi: 10.1083/jcb.200205091. Epub 2002 Nov 18.
94. Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis.
Ferrari D, Pinton P, Szabadkai G, Chami M, Campanella M, Pozzan T, Rizzuto R. Cell Calcium. 2002 Nov-Dec;32(5-6):413-20. doi: 10.1016/s0143416002002014. 93. Ca2+ on the move: ways and means to translate a multifarious signal. Rizzuto R, Pozzan T, Carafoli E. Trends Pharmacol Sci. 2002 Aug;23(8):348-50. doi: 10.1016/s0165-6147(02)02063-1.
92. Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells.
Pinton P, Tsuboi T, Ainscow EK, Pozzan T, Rizzuto R, Rutter GA. J Biol Chem. 2002 Oct 4;277(40):37702-10. doi: 10.1074/jbc.M204478200. Epub 2002 Jul 30.
91. Androgen receptor with elongated polyglutamine tract forms aggregates that alter axonal trafficking and mitochondrial distribution in motor neuronal processes.
Piccioni F, Pinton P, Simeoni S, Pozzi P, Fascio U, Vismara G, Martini L, Rizzuto R, Poletti A. FASEB J. 2002 Sep;16(11):1418-20. doi: 10.1096/fj.01-1035fje. Epub 2002 Jul 18.
90. A role for calcium in Bcl-2 action?
Pinton P, Ferrari D, Rapizzi E, Di Virgilio F, Pozzan T, Rizzuto R. Biochimie. 2002 Feb-Mar;84(2-3):195-201. doi: 10.1016/s0300-9084(02)01373-1.
89. Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera.
Mitchell KJ, Pinton P, Varadi A, Tacchetti C, Ainscow EK, Pozzan T, Rizzuto R, Rutter GA. J Cell Biol. 2001 Oct 1;155(1):41-51. doi: 10.1083/jcb.200103145. Epub 2001 Sep 24.
88. Mitochondrial calcium homeostasis: mechanisms and molecules.
Vandecasteele G, Szabadkai G, Rizzuto R. IUBMB Life. 2001 Sep-Nov;52(3-5):213-9. doi: 10.1080/15216540152846028.
87. Molecular genetics of Ca(2+) stores and intracellular Ca(2+) signalling.
Sorrentino V, Rizzuto R. Trends Pharmacol Sci. 2001 Sep;22(9):459-64. doi: 10.1016/s0165-6147(00)01760-0.
86. Baseline cytosolic Ca2+ oscillations derived from a non-endoplasmic reticulum Ca2+ store.
Missiaen L, Van Acker K, Parys JB, De Smedt H, Van Baelen K, Weidema AF, Vanoevelen J, Raeymaekers L, Renders J, Callewaert G, Rizzuto R, Wuytack F. J Biol Chem. 2001 Oct 19;276(42):39161-70. doi: 10.1074/jbc.M104044200. Epub 2001 Aug 20.
85. SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis.
Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Bréchot C, Paterlini-Bréchot P. J Cell Biol. 2001 Jun 11;153(6):1301-14. doi: 10.1083/jcb.153.6.1301.
84. Intracellular Ca(2+) pools in neuronal signalling.
Rizzuto R. Curr Opin Neurobiol. 2001 Jun;11(3):306-11. doi: 10.1016/s0959-4388(00)00212-9.
83. The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action.
Pinton P, Ferrari D, Rapizzi E, Di Virgilio F, Pozzan T, Rizzuto R. EMBO J. 2001 Jun 1;20(11):2690-701. doi: 10.1093/emboj/20.11.2690.
82. Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling.
Chiesa A, Rapizzi E, Tosello V, Pinton P, de Virgilio M, Fogarty KE, Rizzuto R. Biochem J. 2001 Apr 1;355(Pt 1):1-12. doi: 10.1042/0264-6021:3550001.
81. Mitochondria and calcium homeostasis: a tale of three luminescent proteins.
Magalhães PJ, Rizzuto R. Luminescence. 2001 Mar-Apr;16(2):67-71. doi: 10.1002/bio.614.
80. Intracellular calcium store depletion and acrosome reaction in human spermatozoa: role of calcium and plasma membrane potential.
Rossato M, Di Virgilio F, Rizzuto R, Galeazzi C, Foresta C. Mol Hum Reprod. 2001 Feb;7(2):119-28. doi: 10.1093/molehr/7.2.119.
79. Targeting of reporter molecules to mitochondria to measure calcium, ATP, and pH.
Porcelli AM, Pinton P, Ainscow EK, Chiesa A, Rugolo M, Rutter GA, Rizzuto R. Methods Cell Biol. 2001;65:353-80. doi: 10.1016/s0091-679x(01)65021-0.
78. Mitochondria as all-round players of the calcium game.
Rizzuto R, Bernardi P, Pozzan T. J Physiol. 2000 Nov 15;529 Pt 1(Pt 1):37-47. doi: 10.1111/j.1469-7793.2000.00037.x.
77. The comeback of mitochondria to calcium signalling.
Pozzan T, Magalhães P, Rizzuto R. Cell Calcium. 2000 Nov-Dec;28(5-6):279-83. doi: 10.1054/ceca.2000.0166.
76. Effects of PMCA and SERCA pump overexpression on the kinetics of cell Ca(2+) signalling.
Brini M, Bano D, Manni S, Rizzuto R, Carafoli E. EMBO J. 2000 Sep 15;19(18):4926-35. doi: 10.1093/emboj/19.18.4926.
75. The renaissance of mitochondrial calcium transport.
Pozzan T, Rizzuto R. Eur J Biochem. 2000 Sep;267(17):5269-73. doi: 10.1046/j.1432-1327.2000.01567.x.
74. Regulation of mitochondrial metabolism by ER Ca2+ release: an intimate connection.
Rutter GA, Rizzuto R. Trends Biochem Sci. 2000 May;25(5):215-21. doi: 10.1016/s0968-0004(00)01585-1.
73. Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.
Pinton P, Ferrari D, Magalhães P, Schulze-Osthoff K, Di Virgilio F, Pozzan T, Rizzuto R. J Cell Biol. 2000 Mar 6;148(5):857-62. doi: 10.1083/jcb.148.5.857.
72. High tide of calcium in mitochondria.
Pozzan T, Rizzuto R. Nat Cell Biol. 2000 Feb;2(2):E25-7. doi: 10.1038/35000095.
71. Recombinant aequorin as tool for monitoring calcium concentration in subcellular compartments.
Robert V, Pinton P, Tosello V, Rizzuto R, Pozzan T. Methods Enzymol. 2000;327:440-56. doi: 10.1016/s0076-6879(00)27295-9.
70. Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming.
Jouaville LS, Pinton P, Bastianutto C, Rutter GA, Rizzuto R. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13807-12. doi: 10.1073/pnas.96.24.13807.
69. Mitochondria as biosensors of calcium microdomains.
Rizzuto R, Pinton P, Brini M, Chiesa A, Filippin L, Pozzan T. Cell Calcium. 1999 Nov;26(5):193-9. doi: 10.1054/ceca.1999.0076.
68. Targeted recombinant aequorins: tools for monitoring [Ca2+] in the various compartments of a living cell.
Brini M, Pinton P, Pozzan T, Rizzuto R. Microsc Res Tech. 1999 Sep 15;46(6):380-9. doi: 10.1002/(SICI)1097-0029(19990915)46:6<380::AID-JEMT6>3.0.CO;2-Y.
67. A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
Brini M, Pinton P, King MP, Davidson M, Schon EA, Rizzuto R. Nat Med. 1999 Aug;5(8):951-4. doi: 10.1038/11396.
66. Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria.
Kennedy HJ, Pouli AE, Ainscow EK, Jouaville LS, Rizzuto R, Rutter GA. J Biol Chem. 1999 May 7;274(19):13281-91. doi: 10.1074/jbc.274.19.13281.
65. Targeting GFP to organelles.
De Giorgi F, Ahmed Z, Bastianutto C, Brini M, Jouaville LS, Marsault R, Murgia M, Pinton P, Pozzan T, Rizzuto R. Methods Cell Biol. 1999;58:75-85. doi: 10.1016/s0091-679x(08)61949-4.
64. Calcium and organelles: a two-sided story.
Rutter GA, Fasolato C, Rizzuto R. Biochem Biophys Res Commun. 1998 Dec 30;253(3):549-57. doi: 10.1006/bbrc.1998.9727.
63. The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum.
Pinton P, Pozzan T, Rizzuto R. EMBO J. 1998 Sep 15;17(18):5298-308. doi: 10.1093/emboj/17.18.5298.
62. Integrating cytosolic calcium signals into mitochondrial metabolic responses.
Robb-Gaspers LD, Burnett P, Rutter GA, Denton RM, Rizzuto R, Thomas AP. EMBO J. 1998 Sep 1;17(17):4987-5000. doi: 10.1093/emboj/17.17.4987.
61. Digital imaging microscopy of living cells.
Rizzuto R, Carrington W, Tuft RA. Trends Cell Biol. 1998 Jul;8(7):288-92. doi: 10.1016/s0962-8924(98)01301-4.
60. Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA, Pozzan T. Science. 1998 Jun 12;280(5370):1763-6. doi: 10.1126/science.280.5370.1763.
59. New light on mitochondrial calcium.
Pinton P, Brini M, Bastianutto C, Tuft RA, Pozzan T, Rizzuto R. Biofactors. 1998;8(3-4):243-53. doi: 10.1002/biof.5520080312.
58. BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+.
Lièvremont JP, Rizzuto R, Hendershot L, Meldolesi J. J Biol Chem. 1997 Dec 5;272(49):30873-9. doi: 10.1074/jbc.272.49.30873.
57. Ca2+ homeostasis in the endoplasmic reticulum: coexistence of high and low [Ca2+] subcompartments in intact HeLa cells.
Montero M, Alvarez J, Scheenen WJ, Rizzuto R, Meldolesi J, Pozzan T. J Cell Biol. 1997 Nov 3;139(3):601-11. doi: 10.1083/jcb.139.3.601.
56. Helicobacter pylori toxin VacA induces vacuole formation by acting in the cell cytosol.
De Bernard M, Arico B, Papini E, Rizzuto R, Grandi G, Rappuoli R, Montecucco C. Mol Microbiol. 1997 Nov;26(4):665-74. doi: 10.1046/j.1365-2958.1997.5881952.x.
55. Chimeric calsequestrin and its targeting to the junctional sarcoplasmic reticulum of skeletal muscle.
Nori A, Nadalini KA, Martini A, Rizzuto R, Villa A, Volpe P. Am J Physiol. 1997 May;272(5 Pt 1):C1420-8. doi: 10.1152/ajpcell.1997.272.5.C1420.
54. Domains of high Ca2+ beneath the plasma membrane of living A7r5 cells.
Marsault R, Murgia M, Pozzan T, Rizzuto R. EMBO J. 1997 Apr 1;16(7):1575-81. doi: 10.1093/emboj/16.7.1575.
53. Subcellular analysis of Ca2+ homeostasis in primary cultures of skeletal muscle myotubes.
Brini M, De Giorgi F, Murgia M, Marsault R, Massimino ML, Cantini M, Rizzuto R, Pozzan T. Mol Biol Cell. 1997 Jan;8(1):129-43. doi: 10.1091/mbc.8.1.129.
52. Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells.
Kennedy ED, Rizzuto R, Theler JM, Pralong WF, Bastianutto C, Pozzan T, Wollheim CB. J Clin Invest. 1996 Dec 1;98(11):2524-38. doi: 10.1172/JCI119071.
51. Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity.
Rutter GA, Burnett P, Rizzuto R, Brini M, Murgia M, Pozzan T, Tavaré JM, Denton RM. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5489-94. doi: 10.1073/pnas.93.11.5489.
50. A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells.
Lawrie AM, Rizzuto R, Pozzan T, Simpson AW. J Biol Chem. 1996 May 3;271(18):10753-9. doi: 10.1074/jbc.271.18.10753.
49. Mitochondrial alterations induced by aspirin in rat hepatocytes expressing mitochondrially targeted green fluorescent protein (mtGFP).
Venerando R, Miotto G, Pizzo P, Rizzuto R, Siliprandi N. FEBS Lett. 1996 Mar 18;382(3):256-60. doi: 10.1016/0014-5793(96)00182-2.
48. Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo.
Rizzuto R, Brini M, De Giorgi F, Rossi R, Heim R, Tsien RY, Pozzan T. Curr Biol. 1996 Feb 1;6(2):183-8. doi: 10.1016/s0960-9822(02)00451-7.
47. Targeting aequorin and green fluorescent protein to intracellular organelles.
De Giorgi F, Brini M, Bastianutto C, Marsault R, Montero M, Pizzo P, Rossi R, Rizzuto R. Gene. 1996;173(1 Spec No):113-7. doi: 10.1016/0378-1119(95)00687-7.
46. Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells.
Montero M, Brini M, Marsault R, Alvarez J, Sitia R, Pozzan T, Rizzuto R. EMBO J. 1995 Nov 15;14(22):5467-75.
45. Overexpression of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+ stores and reveals aspects of their lumenal microenvironment and function.
Bastianutto C, Clementi E, Codazzi F, Podini P, De Giorgi F, Rizzuto R, Meldolesi J, Pozzan T. J Cell Biol. 1995 Aug;130(4):847-55. doi: 10.1083/jcb.130.4.847.
44. Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells.
Rizzuto R, Brini M, Pizzo P, Murgia M, Pozzan T. Curr Biol. 1995 Jun 1;5(6):635-42. doi: 10.1016/s0960-9822(95)00128-x.
43. Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation.
Brini M, Marsault R, Bastianutto C, Alvarez J, Pozzan T, Rizzuto R. J Biol Chem. 1995 Apr 28;270(17):9896-903. doi: 10.1074/jbc.270.17.9896.
42. Targeted recombinant aequorins represent to date the most specific means of monitoring [Ca2+] in subcellular organelles. Rizzuto, R., Simpson, A. W. M., Brini, M., and Pozzan, T. (1992) Nature 358, 325-328
41. Expression of cytochrome c oxidase during growth and development of Dictyostelium.
Sandonà D, Gastaldello S, Rizzuto R, Bisson R. J Biol Chem. 1995 Mar 10;270(10):5587-93. doi: 10.1074/jbc.270.10.5587.
40. Photoprotein-mediated measurement of calcium ion concentration in mitochondria of living cells.
Rizzuto R, Brini M, Bastianutto C, Marsault R, Pozzan T. Methods Enzymol. 1995;260:417-28. doi: 10.1016/0076-6879(95)60155-4. 39. Nuclear targeting of aequorin. A new approach for measuring nuclear Ca2+ concentration in intact cells. Brini M, Marsault R, Bastianutto C, Pozzan T, Rizzuto R. Cell Calcium. 1994 Oct;16(4):259-68. doi: 10.1016/0143-4160(94)90089-2.
38. Mitochondrial Ca2+ homeostasis in intact cells.
Rizzuto R, Bastianutto C, Brini M, Murgia M, Pozzan T. J Cell Biol. 1994 Sep;126(5):1183-94. doi: 10.1083/jcb.126.5.1183.
37. Cytosolic free calcium concentration in the mitogenic stimulation of T lymphocytes by anti-CD3 monoclonal antibodies.
Murgia M, Mion M, Veronese L, Panozzo M, Coppola V, Rizzuto R, Brini M, Malavasi F, Amadori A, Chieco Bianchi L, et al. Cell Calcium. 1994 Sep;16(3):167-80. doi: 10.1016/0143-4160(94)90020-5.
36. Molecular and cellular physiology of intracellular calcium stores.
Pozzan T, Rizzuto R, Volpe P, Meldolesi J. Physiol Rev. 1994 Jul;74(3):595-636. doi: 10.1152/physrev.1994.74.3.595.
35. Targeting of aequorin for calcium monitoring in intracellular compartments.
Brini M, Pasti L, Bastianutto C, Murgia M, Pozzan T, Rizzuto R. J Biolumin Chemilumin. 1994 May-Jun;9(3):177-84. doi: 10.1002/bio.1170090312.
34. Gene transfer into satellite cell from regenerating muscle: bupivacaine allows beta-Gal transfection and expression in vitro and in vivo.
Cantini M, Massimino ML, Catani C, Rizzuto R, Brini M, Carraro U. In Vitro Cell Dev Biol Anim. 1994 Feb;30A(2):131-3. doi: 10.1007/BF02631405.
33. Targeting recombinant aequorin to specific intracellular organelles.
Rizzuto R, Brini M, Pozzan T. Methods Cell Biol. 1994;40:339-58. doi: 10.1016/s0091-679x(08)61121-8.
32. Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin.
Brini M, Murgia M, Pasti L, Picard D, Pozzan T, Rizzuto R. EMBO J. 1993 Dec;12(12):4813-9.
31. Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Rizzuto R, Brini M, Murgia M, Pozzan T. Science. 1993 Oct 29;262(5134):744-7. doi: 10.1126/science.8235595.
30. Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion.
Rutter GA, Theler JM, Murgia M, Wollheim CB, Pozzan T, Rizzuto R. J Biol Chem. 1993 Oct 25;268(30):22385-90.
28. Structure of the promoter region of the gene encoding cytochrome c oxidase subunit V in Dictyostelium.
Rizzuto R, Sandonà D, Brini M, Marschalek R, Dingermann T, Bisson R. Eur J Biochem. 1993 Feb 1;211(3):411-4. doi: 10.1111/j.1432-1033.1993.tb17564.x.
27. Intracellular targeting of the photoprotein aequorin: A new approach for measuring, in living cells, Ca(2+) concentrations in defined cellular compartments.
Rizzuto R, Brini M, Pozzan T. Cytotechnology. 1993 Jan;11(Suppl 1):S44-6. doi: 10.1007/BF00746051.
26. Intracellular targeting of the photoprotein aequorin: a new approach for measuring, in living cells, Ca2+ concentrations in defined cellular compartments.
Rizzuto R, Brini M, Pozzan T. Cytotechnology. 1993;11 Suppl 1:S44-6.
25. Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase.
Fabrizi GM, Sadlock J, Hirano M, Mita S, Koga Y, Rizzuto R, Zeviani M, Schon EA. Gene. 1992 Oct 1;119(2):307-12. doi: 10.1016/0378-1119(92)90288-z.
24. Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin.
Rizzuto R, Simpson AW, Brini M, Pozzan T. Nature. 1992 Jul 23;358(6384):325-7. doi: 10.1038/358325a0.
23. Mitochondrial DNA is not fragmented during apoptosis.
Murgia M, Pizzo P, Sandoná D, Zanovello P, Rizzuto R, Di Virgilio F. J Biol Chem. 1992 Jun 5;267(16):10939-41.
22. The most conserved nuclear-encoded polypeptide of cytochrome c oxidase is the putative zinc-binding subunit: primary structure of subunit V from the slime mold Dictyostelium discoideum.
Rizzuto R, Sandonà D, Brini M, Capaldi RA, Bisson R. Biochim Biophys Acta. 1991 Dec 2;1129(1):100-4. doi: 10.1016/0167-4781(91)90220-g.
21. Biological markers of oxidative stress in mitochondrial myopathies with progressive external ophthalmoplegia.
Piccolo G, Banfi P, Azan G, Rizzuto R, Bisson R, Sandoná D, Bellomo G. J Neurol Sci. 1991 Sep;105(1):57-60. doi: 10.1016/0022-510x(91)90118-q.
20. Nucleotide sequence of a cDNA coding for the mitochondrial precursor protein of cytochrome c oxidase subunit IV from the slime mold Dictyostelium discoideum.
Rizzuto R, Sandonà D, Capaldi RA, Bisson R. Biochim Biophys Acta. 1991 Aug 27;1090(1):125-8.
19. Multimodal evoked potentials in progressive external ophthalmoplegia with mitochondrial myopathy.
Versino M, Piccolo G, Callieco R, Bergamaschi R, Banfi P, Azan G, Rizzuto R, Cosi V. Acta Neurol Scand. 1991 Aug;84(2):107-10. doi: 10.1111/j.1600-0404.1991.tb04917.x.
18. Characterization of a cDNA encoding subunit VI of cytochrome c oxidase from the slime mold Dictyostelium discoideum.
Rizzuto R, Sandonà D, Capaldi RA, Bisson R. Biochim Biophys Acta. 1991 Jul 23;1089(3):386-8. doi: 10.1016/0167-4781(91)90180-t.
17. Nucleotide sequence of the cDNA encoding subunit VIIe of cytochrome c oxidase from the slime mold Dictyostelium discoideum.
Rizzuto R, Sandonà D, Capaldi RA, Bisson R. Nucleic Acids Res. 1990 Nov 25;18(22):6711. doi: 10.1093/nar/18.22.6711.
16. Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: implications for pathogenesis.
Nakase H, Moraes CT, Rizzuto R, Lombes A, DiMauro S, Schon EA. Am J Hum Genet. 1990 Mar;46(3):418-27.
15. The two oxygen-regulated subunits of cytochrome c oxidase in Dictyostelium discoideum derive from a common ancestor.
Capaldi RA, Zhang YZ, Rizzuto R, Sandonà D, Schiavo G, Bisson R. FEBS Lett. 1990 Feb 12;261(1):158-60. doi: 10.1016/0014-5793(90)80660-b.
14. Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA.
Mita S, Rizzuto R, Moraes CT, Shanske S, Arnaudo E, Fabrizi GM, Koga Y, DiMauro S, Schon EA. Nucleic Acids Res. 1990 Feb 11;18(3):561-7. doi: 10.1093/nar/18.3.561.
13. Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase.
Fabrizi GM, Rizzuto R, Nakase H, Mita S, Lomax MI, Grossman LI, Schon EA. Nucleic Acids Res. 1989 Sep 12;17(17):7107. doi: 10.1093/nar/17.17.7107.
12. Sequence of a cDNA specifying subunit VIa of human cytochrome c oxidase.
Fabrizi GM, Rizzuto R, Nakase H, Mita S, Kadenbach B, Schon EA. Nucleic Acids Res. 1989 Aug 11;17(15):6409. doi: 10.1093/nar/17.15.6409.
11. A gene specifying subunit VIII of human cytochrome c oxidase is localized to chromosome 11 and is expressed in both muscle and non-muscle tissues.
Rizzuto R, Nakase H, Darras B, Francke U, Fabrizi GM, Mengel T, Walsh F, Kadenbach B, DiMauro S, Schon EA. J Biol Chem. 1989 Jun 25;264(18):10595-600.
10. A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA. Schon EA, Rizzuto R, Moraes CT, Nakase H, Zeviani M, DiMauro S. Science. 1989 Apr 21;244(4902):346-9. doi: 10.1126/science.2711184.
9. Mitochondrial encephalomyopathies.
DiMauro S, Zeviani M, Moraes CT, Nakase H, Rizzuto R, Lombes A, Shanske S, Schon EA. Prog Clin Biol Res. 1989;306:117-28.
8. Subunit Va of human and bovine cytochrome c oxidase is highly conserved.
Rizzuto R, Nakase H, Zeviani M, DiMauro S, Schon EA. Gene. 1988 Sep 30;69(2):245-56. doi: 10.1016/0378-1119(88)90435-0.
7. Molecular defects in cytochrome oxidase in mitochondrial diseases.
DiMauro S, Zeviani M, Rizzuto R, Lombes A, Nakase H, Bonilla E, Miranda A, Schon E. J Bioenerg Biomembr. 1988 Jun;20(3):353-64. doi: 10.1007/BF00769637.
6. Sequence of cDNAs encoding subunit Vb of human and bovine cytochrome c oxidase.
Zeviani M, Sakoda S, Sherbany AA, Nakase H, Rizzuto R, Samitt CE, DiMauro S, Schon EA. Gene. 1988 May 15;65(1):1-11. doi: 10.1016/0378-1119(88)90411-8.
5. Cloning and expression of human nebulin cDNAs and assignment of the gene to chromosome 2q31-q32.
Zeviani M, Darras BT, Rizzuto R, Salviati G, Betto R, Bonilla E, Miranda AF, Du J, Samitt C, Dickson G, et al. Genomics. 1988 Apr;2(3):249-56. doi: 10.1016/0888-7543(88)90009-2.
4. Clinical and biochemical studies on cytochrome oxidase deficiencies.
Schon EA, Bonilla E, Lombes A, Moraes CT, Nakase H, Rizzuto R, Zeviani M, DiMauro S. Ann N Y Acad Sci. 1988;550:348-59. doi: 10.1111/j.1749-6632.1988.tb35349.x.
3. Pathways for Ca2+ efflux in heart and liver mitochondria.
Rizzuto R, Bernardi P, Favaron M, Azzone GF. Biochem J. 1987 Sep 1;246(2):271-7. doi: 10.1042/bj2460271.
2. Effect of Ca2+, peroxides, SH reagents, phosphate and aging on the permeability of mitochondrial membranes.
Rizzuto R, Pitton G, Azzone GF. Eur J Biochem. 1987 Jan 15;162(2):239-49. doi: 10.1111/j.1432-1033.1987.tb10591.x.
1. Lesch-Nyhan syndrome: clinico-metabolic study of a case.
Bonavita V, Terzian H, Cotrufo R, Rizzuto R, Vio M. Acta Neurol (Napoli). 1973 May-Jun;28(3):350-64.
2020: Commander of the order of merit of the Italian Republic
2014: Antonio Feltrinelli Award of the Accademia dei Lincei
2004: Theodore Bucher Medal
2002: Chiara D’Onofrio Prize for major contributions in the field of molecular and cellular biology
2001: Biotec Award
2013-date: Member of the European Molecular Biology Organization (EMBO)
2008-date: Member of the Academia Europaea, Section of Physiology and Medicine
My research activity has been supported through the year by grants from the European Research Council (ERC Ideas Advanced grant - MitoCALCIUM: Mitochondrial calcium signalling: molecules, roles and pharmacological targeting), the EU FP programs, the National Institute of Health, The Italian Association for Cancer Research (AIRC), Telethon- Italy, the Italian Education and Health Ministries and the Cariparo and Cariplo bank foundations.
