My research aims at understanding complex cellular processes via comprehensive description of protein interactions and dynamics. We study the role of protein condensation in biochemical pathways and the pathological conversion of liquid droplets. We also develop sequence-based prediction methods to identify fuzzy interactions from sequence and protein regions capable of mediating liquid-liquid phase separation.
M. Fuxreiter and M. Vendruscolo (2021) Generic nature of the condensed state of proteins. Nat Cell Biol 23, 587-594.
Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. (2018) Protein phase separation: a new phase in cell biology. Trends Cell Biol. 28, 420-435.
M. Hardenberg, A. Horvath, V. Ambrus, M. Fuxreiter, M. Vendruscolo (2020) Wide-spread occurrence of the droplet state of proteins in the human proteome. PNAS. 117(52), 33254-33262. doi: 10.1073/pnas.2007670117
Gianni S, Freiberger MI, Jemth P, Ferreiro DU, Wolynes PG,Fuxreiter M. (2021) Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly. Acc Chem Res. doi: 10.1021/acs.accounts.0c00813
Wu, H, Fuxreiter M (2016) The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules. Cell 165, 1055-1066.
- FuzDB: Fuzzy interactions database
- FuzDrop: prediction of the probability to undergo liquid-liquid phase separation
- FuzPred: prediction of protein interaction behaviors
- Generic nature of the condensed state of proteins
- Anything new about protein interactions?
